Bence Jones Protein, Spot Urine
Bence Jones Protein, Spot Urine
The Bence Jones protein test is used to detect and quantify the presence of free monoclonal immunoglobulin light chains in urine. The test is usually performed on a spot urine sample, which is a single sample collected at a specific time. Bence Jones proteins are monoclonal immunoglobulin light chains found in the urine of individuals with certain types of plasma cell disorders, such as multiple myeloma (a type of blood cancer) or other related conditions. Immunoglobulins are proteins produced by plasma cells, which are a type of white blood cell. Â Â
This test helps in the diagnosis and monitoring of plasma cell disorders, especially multiple myeloma
Signs and symptoms of multiple myeloma
Bone pain, especially in the back, chest, or hips
Nausea
Constipation
Loss of appetite
Confusion
Tiredness
Frequent infections
Weight loss
Excessive thirst
Needing to urinate often
High blood calcium
Low levels of red or white blood cells or platelets
What is Bence Jones Protein, Spot Urine test used for?
Bence Jones protein, spot urine test is performed:
To confirm multiple myeloma in individuals exhibiting symptoms
To diagnose conditions that cause loss of protein in the urine
Test preparation
No special preparation is required for this test. Ensure that your doctor is aware of the prescription drugs, over-the-counter medicines, or dietary supplements you are taking
Interpretation of the Test Results
Normal Results
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A normal result indicates that no Bence Jones proteins are found in the urine.
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Abnormal Results Â
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An abnormal result indicates the presence of Bence Jones proteins in urine. Abnormal results are usually associated with multiple myeloma.
 An abnormal Bence Jones proteins result may also be due to:Â
·      Accumulation of proteins in tissues and organs, leading to abnormal build-up (amyloidosis)
·      Chronic lymphocytic leukaemia, a type of blood cancer
·      Cancer affecting the lymphatic system (lymphoma)
·      Excessive presence of M-protein in the blood (monoclonal gammopathy of unknown significance; MGUS)
·      Chronic renal failure
FAQs
How is the sample collected for the Bence Jones proteins, spot urine test?
A urine sample is used for this test. You will be given a sterile container by your healthcare provider to collect a urine sample.
Midstream urine collection is the proper technique for taking a urine sample. The first few urine drops should be discarded because they could contain microorganisms that are present on the genital surface. It is advised that you clean the area around the genitalia before taking a urine sample
What are the risks involved in the Bence Jones proteins, spot urine test sample collection?
Urine sample collection for Bence Jones proteins, spot urine test does not pose any risks
What is the turnaround time (TAT) for the results of the Bence Jones proteins, spot urine test?
Bence Jones proteins, spot urine test results are usually available in 1-2 working days after sample collection. This duration may vary depending upon the diagnostic clinic
Can Bence Jones proteins disappear with treatment?
In some cases, successful treatment of the underlying plasma cell disorder can lead to a reduction or disappearance of Bence Jones proteins in the urine. Regular monitoring and follow-up are important to assess treatment response
How is multiple myeloma treated if Bence Jones proteins are detected?
Treatment for multiple myeloma typically involves a combination of chemotherapy, immunomodulatory drugs, steroids, and stem cell transplantation. The specific treatment plan depends on various factors, including the individual's overall health. It is advised to consult your healthcare provider for tailored treatment based on your specific results
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